The game has a different protag and plot. There are cameo appearances by some characters(Hershel) from the tv series/graphic novels though (1 or 2 of them so far?) I think the way they are characterized in the game fully mirrors their personality in the graphic novel... I dunno if you will consider that a spoiler! Disclaimer: I only read the graphic novels and played episode 1 of the game on PC. I have been told the TV series is a very loyal adaptation of the graphic novel though.