I've unlocked all I've the cards not counting booster packs and I've been trying more Souls Rift with Admiral; I have no idea how to make it work because most of the draft cards are just skill damage cards. It would be great if the card buckets at the end of battle featured more anti-curse cards considering the fact that this stage is half about dealing with curses. The plethora of skill damage cards in the buckets do not really deal with curses at all. I've played about 3 run-throughs and the only actual way to discard curses has been through the Dice relic, which is not even a dedicated anti-curse item. It's pretty strange because my previous runs in which I hadn't unlocked all the cards, Souls Rift card buckets actually provided a few cards that could deal with curses. Now every run through I lose when I get to the statues because I have not been able to draft or buy any anti-curse cards. tl;dr The card rewards in Souls Rift actively work against you and don't feature much anti-curse cards despite it being the most curse-heavy stage. Also I've entered the Plague curse cave with the 4 upgrades with an Amulet, but the first option didn't pop up for me.