I've used the same setup with a cheap HD enclosure for like $30, for 2 years now and never had a problem...
Hard drives are hard drives. It doesn't matter what they're intended to be used in, if you can hook it up to something, you can use it however you like.
Even if I will be talking it everywhere like a portable external. I was going to get a WD my passport but then I thaught of this. Btw it will be used at home school and on my xbox 360
so anyone want to point me in the right direction for some super cheap 2.5 inch sata drives 20GB + please