I have a macbook pro that is almost slam full (down to 5-6 GB). I noticed I have tons of Games in itunes that are all over 1GB. If I'm not playing these titles anytime soon, would it be safe to delete them from itunes and not keep the files (to save space). Can I download them later (if they're still available) and keep them on the Mac while I'm playing through them on my iDevice?
Yes you can download them again anytime you like, you'll find them in the purchased tab in the app store from your ios device or iTunes